Through the lens of human-centric digital transformation, this study investigates the shift from Supply Chain 4.0 to Supply Chain 5.0, emphasizing the roles of digital transformation technologies and human-centric practices in propelling this change as well as its implications for supply chain resilience and sustainability. A structured, five-point Likert-scale questionnaire covering Digital Transformation Technologies (DTT), Human-Centric Digital Transformation (HCDT), Transition to Supply Chain 5.0 (SC5T), and Sustainability & Resilience (SSR) was used to gather data from 100 respondents mostly seasoned supply chain professionals using a quantitative, cross-sectional research design. Excellent internal consistency across all constructs was proven by reliability analysis (Cronbach's Alpha > 0.90). All four constructs had robust, statistically significant positive connections, according to descriptive and correlation analyzes.Both null hypotheses were rejected after multiple regression analysis revealed that DTT and HCDT together explained 98.8% of the variance in the shift to Supply Chain 5.0. Both variables emerged as substantial positive predictors. The shift to Supply Chain 5.0 significantly predicts sustainability and resilience outcomes, according to an additional regression. These results imply that while digital technology continue to be the primary force behind supply chain transformation, human-centric integration plays a crucial complementary role and that companies adopting Supply Chain 5.0 see quantifiable increases in sustainability and resilience. In addition to providing useful advice for businesses, politicians, and researchers looking to negotiate a more balanced, human-centered digital transformation, the study adds empirical data to the growing Supply Chain 5.0 discourse.